Laboratory of Mucosal Immunology

Publications

2012

Extrathymically generated regulatory T cells control mucosal TH2 inflammation.
Josefowicz Steven Z, Niec Rachel E, Kim Hye Young, Treuting Piper, Chinen Takatoshi, Zheng Ye, Umetsu Dale T, Rudensky Alexander Y
Nature 2012 2;482:395-9

2012

2011

Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.
Chang Ya-Jen, Kim Hye Young, Albacker Lee A, Lee Hyun Hee, Baumgarth Nicole, Akira Shizuo, Savage Paul B, Endo Shin, Yamamura Takashi, Maaskant Janneke, Kitano Naoki, Singh Abel, Bhatt Apoorva, Besra Gurdyal S, van den Elzen Peter, Appelmelk Ben, Franck Richard W, Chen Guangwu, DeKruyff Rosemarie H, Shimamura Michio, Illarionov Petr, Umetsu Dale T
J. Clin. Invest. 2011 1;121:57-69

2011

A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.
Kim Hye Young, Eyheramonho María Belén, Pichavant Muriel, Gonzalez Cambaceres Carlos, Matangkasombut Ponpan, Cervio Guillermo, Kuperman Silvina, Moreiro Rita, Konduru Krishnamurthy, Manangeeswaran Mohanraj, Freeman Gordon J, Kaplan Gerardo G, DeKruyff Rosemarie H, Umetsu Dale T, Rosenzweig Sergio D
J. Clin. Invest. 2011 3;121:1111-8

2011

nnate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.
Chang Ya-Jen, Kim Hye Young, Albacker Lee A, Baumgarth Nicole, McKenzie Andrew N J, Smith Dirk E, Dekruyff Rosemarie H, Umetsu Dale T
Nat. Immunol. 2011 5;12:631-8

2010

2010

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.
Lee Hyun-Hee, Meyer Everett H, Goya Sho, Pichavant Muriel, Kim Hye Young, Bu Xia, Umetsu Sarah E, Jones Jennifer C, Savage Paul B, Iwakura Yoichiro, Casasnovas Jose M, Kaplan Gerardo, Freeman Gordon J, DeKruyff Rosemarie H, Umetsu Dale T
J. Immunol. 2010 11;185:5225-35

2010

Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.
Lee Hyun-Hee, Meyer Everett H, Goya Sho, Pichavant Muriel, Kim Hye Young, Bu Xia, Umetsu Sarah E, Jones Jennifer C, Savage Paul B, Iwakura Yoichiro, Casasnovas Jose M, Kaplan Gerardo, Freeman Gordon J, DeKruyff Rosemarie H, Umetsu Dale T
J. Immunol. 2010 11;185:5225-35

2010

2009

Natural killer T cells in the lungs of patients with asthma.
Matangkasombut Ponpan, Marigowda Gautham, Ervine Aaron, Idris Luaie, Pichavant Muriel, Kim Hye Young, Yasumi Takahiro, Wilson S Brian, DeKruyff Rosemarie H, Faul John L, Israel Elliot, Akbari Omid, Umetsu Dale T
J. Allergy Clin. Immunol. 2009 5;123:1181-5

2009

The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells.
Kim Hye Young, Pichavant Muriel, Matangkasombut Ponpan, Koh Youngil I, Savage Paul B, DeKruyff Rosemarie H, Umetsu Dale T
J. Immunol. 2009 3;182:3252-61

2009

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
He Rui, Kim Hye Young, Yoon Juhan, Oyoshi Michiko K, MacGinnitie Andrew, Goya Sho, Freyschmidt Eva-Jasmin, Bryce Paul, McKenzie Andrew N J, Umetsu Dale T, Oettgen Hans C, Geha Raif S
J. Allergy Clin. Immunol. 2009 10;124:761-70.e1

2008

Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.
Pichavant Muriel, Goya Sho, Meyer Everett H, Johnston Richard A, Kim Hye Y, Matangkasombut Ponpan, Zhu Ming, Iwakura Yoichiro, Savage Paul B, DeKruyff Rosemarie H, Shore Stephanie A, Umetsu Dale T
J. Exp. Med. 2008 2;205:385-93

2008

Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice.
Koh Youngil I, Kim Hye Young, Meyer Everett H, Pichavant Muriel, Akbari Omid, Yasumi Takahiro, Savage Paul B, DeKruyff Rosemarie H, Umetsu Dale T
J. Immunol. 2008 10;181:4560-4569

2006

2006

Engagement of glucocorticoid-induced TNF receptor costimulates NKT cell activation in vitro and in vivo.
Kim Hyun Jung, Kim Hye Young, Kim Byoung Kwon, Kim Sanghee, Chung Doo Hyun
J. Immunol. 2006 3;176:3507-15

2005

Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma.
Kim Ji Hyung, Kim Hye Young, Kim Sanghee, Chung Jin-Haeng, Park Weon Seo, Chung Doo Hyun
Am. J. Pathol. 2005 11;167:1231-41

2005

NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production.
Kim Hye Young, Kim Hyun Jung, Min Hye Sook, Kim Sanghee, Park Weon Seo, Park Seong Hoe, Chung Doo Hyun
J. Exp. Med. 2005 1;201:41-7

2004

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